[Frontiers in Bioscience 11, 1607-1619, May 1, 2006] 1607 Insights into transcriptional regulation by FOXP3
نویسندگان
چکیده
1. Abstract 2. The Fox family of transcription factors 3. Fox Family Members in the Immune System 3.1. FoxD1/2 3.2. FoxN1 3.3. FoxJ1 3.4. FoxO 4. Discovery of the FoxP subfamily 5. Role of FOXP subfamily members in human disease 6. FoxP3: the black sheep of the FoxP subfamily 6.1 Identification of FoxP3 6.2. FoxP3 function 6.3. Role of transcriptional co-repressors in FoxP function 6.4. Structure-function analysis of FOXP3 7. The transcriptional program of FoxP3 – evidence for target genes and effects on regulatory T cell physiology 7.1. The FoxP3 Transcriptome 7.2. FoxP3, apoptosis, and proliferation 7.3. Molecular mediators of suppression and FoxP3 8. Perspective 9. Acknowledgment 10. References
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